Acetyl-L-Carnitine
1000 mgSupports cellular energy for
mental clarity.†
4.8 stars | 120,000+ Bottles Sold
Caffeine-Free Nootropic to Help Support Focus and Mental Clarity.
Formulated by pharmacists using ingredients studied across 187 peer-reviewed publications.
- Sustained focus without caffeine (no crash, no jitters)
- Supports healthy memory and cognitive function†
- Contains ingredients at or above levels used in clinical studies†
- 100-day satisfaction guarantee
- Made in the USA, third‑party tested
What you’ll feel
Many users report feeling calm and focused. Benefits may improve with consistent use.
Clean energy & mental clarity; less distractibility.
Smoother recall, words come faster, mental endurance improves.
Noticeable support for memory formation and complex problem-solving.
Self-reported effects; results vary. Optimal results are achieved after sustained consistency of 4+ weeks.
The Smarter Choice For Your Brain
Why settle for overpriced ceffeine pills or underdosed "nootropics?" Nesis gives you:
Clinically Backed Ingredients
Zero Caffeine
Better Value
It's not hype. It's neuroscience you can feel.
The Science of Modern Fatigue
Ingredients in NESIS® help support your body's natural response to fatigue, stress & mental fog.
75%
of adults report high stress
28%
of adults experience brain fog
25%
of adults feel physical fatigue
*Based on population data from CDC, Global Org for Stress, and Lancet Public Health.
Join 100,000+ Others Boosting Focus, Clarity & Energy
Focus
Clarity
Mood
Trust
Alex Carter
“I used to struggle staying locked in during long meetings, but since starting Nesis I’ve noticed I can actually sit through a full workday without zoning out. It keeps me steady, not wired.”
Verified Purchase
Maya Thompson
“No more post-lunch crash! Afternoons used to be the hardest for me. With Nesis, I still feel sharp at 4 PM, which has never happened before.”
Verified Purchase
Daniel Lee
“Mornings used to feel impossible, but now I can actually sit down, zone in, and finish work without distractions.”
Verified Purchase
Sophia Ramirez
“It feels like the fog finally lifted. My thoughts are sharper and I don’t lose track mid-conversation anymore, which makes me more confident at work.”
Verified Purchase
Ethan Brooks
“Within about 20 minutes of taking it, I feel alert and clear without needing coffee.”
Verified Purchase
Grace Mitchell
“It’s not like a jittery caffeine buzz. It’s more of a steady, clean clarity where I can think clearly and actually stay with a problem until it’s solved.”
Verified Purchase
Ryan Matthews
“I didn't expect it to help with stress, but I actually feel calmer when work piles up. My evenings are lighter too, because I’m not mentally drained.”
Verified Purchase
Isabella Nguyen
“Other nootropics made me edgy, but this one keeps me balanced and present all day.”
Verified Purchase
Liam Parker
“I’ve noticed I’m more patient and less irritable, even on stressful days. That little shift has improved my evenings with family as much as my workday.”
Verified Purchase
Chloe Anderson
“Clean ingredients, nothing hidden. That mattered to me.”
Verified Purchase
Marcus Wright
“I’ve tried a few brain supplements before, but this is the only one that feels reliable and consistent.”
Verified Purchase
Olivia Bennett
“What I like most is the consistency. No side effects, no weird crash. Just steady results that I can count on daily, which is rare for supplements.”
Verified Purchase
DOSE (per 6‑cap serving)
2,000 mg
MECHANISMS
Catecholamine precursor for stress performance
Mechanism of action
Precursor to the catecholamines dopamine and norepinephrine. Under acute stress or sleep restriction, catecholamine demand rises; tyrosine helps maintain neurotransmitter availability, supporting working memory and vigilance. Not a stimulant.
What it supports
- Mental performance under acute stress (cold, multitasking, fatigue)†
- Working memory and vigilance when sleep‑restricted†
- Cognitive flexibility / interference control in some trials†
- Sense of motivation when catecholamine tone is challenged†
Why this dose
2,000 mg is a commonly studied acute amount for stress‑related cognitive tasks and sustained vigilance. It’s high enough to matter, without the heaviness of very large (mg/kg) research doses.
Notes
- Avoid combining with MAO inhibitors.
- May interact with thyroid medication and levodopa—check with a clinician.
- For best uptake, consider taking away from very high‑protein meals.
- Occasional GI upset or mild headache can occur.
Key references
DOSE
1,000 mg
MECHANISMS
Mitochondrial energy & acetyl donor
Mechanism of action
Transports fatty acids into the mitochondria for ATP production and donates acetyl groups that can be used to synthesize acetylcholine. Exhibits neuro‑metabolic and neurotrophic effects and supports peripheral nerve health.
What it supports
- Mental energy and reduced fatigue, especially in older adults†
- Acetylcholine availability (via acetyl donation)†
- Mitochondrial function and cellular energy†
- General mood support in research settings†
Why this dose
Human studies commonly use 500–2,000 mg/day. 1,000 mg sits in the middle of the effective range and pairs well with choline donors in your stack.
Notes
- May cause mild GI upset; take with food if needed.
- Occasional restlessness if taken late—prefer earlier in the day.
- Talk to a clinician if you have thyroid disorders or are on medication.
- Talk to a clinician if you have a history of seizure disorders or are on antiseizure medications.
- Avoid during pregnancy / lactation due to limited data.
Key references
DOSE
600 mg
MECHANISMS
Choline donor for acetylcholine
Mechanism of action
Highly bioavailable choline donor that crosses the blood–brain barrier and supports acetylcholine synthesis and phosphatidylcholine for membranes.
What it supports
- Attention and memory in select contexts†
- Mental clarity and processing under cognitive load†
- Choline status to complement acetyl donors in the stack†
Why this dose
Cognitive studies typically use 300–1,200 mg/day. 600 mg is a strong single‑serving amount for noticeable cholinergic support without excessive cholinergic side effects.
Notes
- Possible headache, nausea, or vivid dreams in cholinergic‑sensitive users.
- Use caution if taking cholinesterase inhibitors or anticholinergic medications.
- Stop if persistent GI issues occur.
Key references
DOSE
350 mg
MECHANISMS
Universal antioxidant & redox cofactor
Mechanism of action
A redox‑active cofactor for mitochondrial dehydrogenase complexes; recycles antioxidants (e.g., glutathione), influences glucose and endothelial pathways, and is both water‑ and fat‑soluble (wide tissue reach).
What it supports
- Healthy oxidative‑stress balance†
- Metabolic & vascular function in research settings†
- Broad mitochondrial support alongside carnitine†
Why this dose
Human trials commonly use 300–600 mg/day. 350 mg delivers meaningful antioxidant/mitochondrial support with good tolerability for daily use.
Notes
- Can lower blood glucose—use caution with diabetes meds and monitor.
- May chelate minerals; separate from iron/zinc supplements by a few hours.
- Occasional heartburn or nausea; take with food if sensitive.
- Avoid in pregnancy / lactation due to limited data.
Key references
DOSE
100 mg
MECHANISMS
Alpha‑wave calm focus without caffeine
Mechanism of action
Crosses the BBB; promotes alpha‑wave activity and modulates glutamate/GABA signaling for a state of calm alertness without sedation.
What it supports
- Relaxed focus and smoother task switching†
- Stress attenuation during demanding tasks†
- Calm without drowsiness; pairs well with stimulant‑free stacks†
Why this dose
100–200 mg is typical in human research. 100 mg provides a clean, repeatable calming effect suitable for daytime focus.
Notes
- Generally, well tolerated. May enhance antihypertensive effects.
- Use caution with sedatives (additive calming).
- Rare headache or lightheadedness at higher intakes.
Key references
DOSE
100 mg
MECHANISMS
Cell‑membrane phospholipid for neuronal signaling
Mechanism of action
Key neuronal membrane phospholipid involved in synaptic signaling, plasticity, and stress‑response modulation (e.g., HPA‑axis/cortisol dynamics).
What it supports
- Memory and recall in older adults / cognitively demanding tasks†
- Attention and processing speed under stress†
- Healthy stress‑response tone†
Why this dose
Research often uses 100 mg, 2–3×/day. Your formula provides 100 mg per serving to layer with other cholinergics and membrane‑supportive nutrients.
Notes
- Many products are sunflower‑ or soy‑derived—check for allergies.
- Usually well tolerated; occasional GI discomfort possible.
- Limited data in pregnancy / lactation.
Key references
DOSE
500 mg
MECHANISMS
Phenolic diterpenes (e.g., carnosic acid) & aroma terpenes
Mechanism of action
Rich in phenolic diterpenes (carnosic acid/carnosol) that activate Nrf2 antioxidant pathways and inhibit cholinesterase; aromatic terpenes may influence attention and mood.
What it supports
- Memory and mental clarity in acute settings†
- Antioxidant and neuroprotective milieu†
- Pleasant alert‑calm state complementary to theanine†
Why this dose
500 mg provides a meaningful amount of diterpenes/aromatics aligned with the cognitive/mood outcomes reported in rosemary trials and mechanistic work.
Notes
- Avoid high‑dose essential‑oil forms; stick to dietary‑type extracts.
- Pregnancy: best avoided due to limited safety at supplemental doses.
- Use caution with seizure disorders (rare terpene sensitivity).
- Possible mild GI upset.
Key references
DOSE
500 mg
MECHANISMS
Calm alertness & mood support
Mechanism of action
Provides rosmarinic acid and other actives with GABA‑transaminase and cholinergic interactions; clinically noted for calming and mood support without strong sedation.
What it supports
- Calm alertness and mood balance†
- Stress and tension relief†
- Sleep quality support in sensitive individuals†
Why this dose
Human studies frequently use 300–600 mg extracts. 500 mg targets noticeable calming while remaining daytime‑friendly.
Notes
- May enhance sedatives; use caution with CNS depressants.
- Limited human data in hypothyroid patients—monitor if applicable.
- Avoid during pregnancy / lactation due to limited data.
Key references
DOSE
500 mg
MECHANISMS
Aromatic monoterpenes; cholinesterase‑modulating activity
Mechanism of action
Aromatic monoterpenes and polyphenols with cholinesterase‑modulating activity and nicotinic/muscarinic receptor interactions; also exhibits antioxidant properties.
What it supports
- Acute memory and attention performance†
- Mood and stress‑battery outcomes in trials†
- Complements cholinergic support from Alpha‑GPC†
Why this dose
Human studies show acute cognitive benefits with standardized extracts and essential‑oil fractions; 500 mg provides robust, food‑range support without pushing terpene load too high.
Notes
- Some species contain thujone—use standardized, food‑grade forms.
- Avoid in pregnancy; use caution with epilepsy or seizure history.
- Be mindful if on cholinesterase inhibitors/anticholinergics.
Key references
DOSE
300 mg
MECHANISMS
Withanolide‑bearing adaptogen for stress resilience
Mechanism of action
Adaptogenic root rich in withanolides that modulate the HPA axis, GABAergic tone, and inflammatory signaling—supporting stress resilience and calm focus.
What it supports
- Reduced stress and anxiety in randomized trials†
- Sleep quality and self‑rated well‑being†
- Cognitive performance under stress (attention/working memory)†
Why this dose
Well‑studied extracts often use 300 mg, once or twice daily, providing clinically relevant withanolide levels with excellent tolerability.
Notes
- Avoid during pregnancy and in active hyperthyroid states (may raise T3/T4).
- Use caution with autoimmune conditions or immunomodulatory meds.
- Can be mildly sedating in some—take earlier to gauge response.
- Rare GI upset.
Key references
10 ingredients, clinically studied, that change everything.
formulated with higher levels
than most supplements.
vegan, keto, gluten,
dairy & caffeine free
quality ingredients,
100% made in the USA
Alpha-GPC
600 mgHelps support brain health
& cognitive energy.†
Alpha-Lipoic Acid
350 mgProvides antioxidant support to
help protect brain cells.†
Ashwagandha
300 mgHelps the body manage stress
and promote balance.†
Lemon Balm
500 mgSupports relaxation
and focus.†
L-Theanine
100 mgPromotes calm &
steady mental energy.†
L-Tyrosine
2000 mgSupports focus and resilience
under stress.†
Phosphatidylserine
100 mgSupports memory &
learning function.†
Rosemary
500 mgProvides antioxidant support
for clarity & recall.†
Sage
500 mgSupports focus and
cognition performance.†
We’re Raising the Bar for Quality
At NESIS®, we hold ourselves to rigorous quality standards. From research and ingredient sourcing to manufacturing and testing, we follow strict practices designed to ensure a consistent, high-quality product you can trust.
1
Clinically-dosed product
10
Ingredients chosen for maximum impact
187
Clinical studies
14
Iterations and counting
Good to Know
Wondering if you can take Nesis® with your morning coffee or tea? Absolutely — it’s caffeine-free.
Thinking about how to take it? Just 6 vegetarian capsules each morning on an empty stomach works best.
Got a sensitive stomach? Start slow: 3 capsules for the first 3 days, then gradually increase to 6 by Day 10.
Fog & Fatigue vs Focus
MEET OUR FOUNDER
Dr. Kevin Bunting Jr.
PharmD, Clinical Pharmacist
When I started on the journey to develop NESIS®, I dove deep into the science and literature of this term I saw everywhere - "nootropics."
After 4 years of exhaustive research and over ten formula iterations, NESIS® was developed after years of research using ingredients supported by peer-reviewed studies. Each ingredient is included at meaningful levels based on existing research.
Frequently Asked Questions
Find quick answers to common questions about NESIS
Our clinically-researched formula is six (6) easy-swallow vegetarian capsules once daily
NO, there is no caffeine in NESIS therefore, once you reach a steady state, (see FAQ question "How long until I start to feel the effects and experience the benefits of NESIS?" for a definition on steady state) you should have a new baseline energy and efficiency at the cellular level.
Overall, you may start to feel the effects the first morning you take NESIS - between 30-60 minutes.
You should see a bit of a cycle at first while your body is reaching what we call a "steady state" in pharmacokinetic terms. This means your body is maintaining an equilibrium of the molecules within the desired levels.
The cycle may look something like this:
Day 1-5: Relative and noticeable increases in your drive, endurance, memory, focus
Day 6+: Your new baseline which may not "feel" as drastic of a change, but has become the new "flow" state for your functionality
Remember, this product is working at the cellular level, and unlike compounds like caffeine, this should not leave you with jittery jolts followed by a massive crash. The goal is an optimized state of being that is steady and sustainable
We recommend taking this once daily on an empty stomach upon awakening. Taking this with your morning tea or coffee is OK.
Honestly, you know your body best. When we were testing our formula, our users fully tolerated the recommended serving. Also, each serving has been thoroughly researched to be safe and effective at these amounts*
If you are uncomfortable starting at the full serving, we recommend the following serving schedule:
Three (3) capsules once daily for days 1-3
Four (4) capsules once daily for days 4-6
Five (5) capsules once daily for days 7-9
Six (6) capsules once daily starting on day 10
You should be taking NESIS daily. In reality, it's only our first four (4) ingredients (L-tyrosine, acetyl-L-carnitine, alpha GPC, and alpha-lipoic acid) that should yield any perceived feelings up front. The remaining six (6) ingredients target more along the chronic stress pathways and chronic systemic inflammation pathways.
In other words, you taking NESIS PRN (as needed) will only give you short-term benefits. If you'd like to optimize to the complete vision of NESIS and also seek out cognitive longevity benefits, we recommend daily use.
Absolutely, since NESIS has zero (0) mg of caffeine, it is safe to consume your normal amount of daily caffeine.
Please speak to your local pharmacist or physician to clarify. We worked very hard to ensure these ingredients have the lowest number of interactions and contraindications, however, this falls into a case-by-case basis.
A few of our ingredients have been shown to improve insulin sensitivity and suppress gluconeogenesis (production of glucose), therefore may lower blood glucose levels and should be monitored. It is best to speak with your primary physician helping manage your glucose levels to ensure this product is safe for you.
Please speak to your neurologist regarding NESIS supplementation. They will be able to help guide based on your specific seizure disorder (i.e. tonic-clonic, absence, etc.)
If you remember within 8 hours of your normal time to take NESIS INCEPTION, you are OK to take the missed serving.
Example: Normal serving time: NESIS at 0600, remember at lunchtime, OK to take
Example: Normal serving time: NESIS at 0600, remember at dinnertime, SKIP and restart regimen on the following day
NOTE: The reason we tell you to skip the serving is not because of safety issues, it's more related to the idea that you want to take NESIS INCEPTION at the start of your day when you're most alert, not when you're about to unwind and maintain good sleep hygiene.
Yes. The ingredient alpha GPC is a precursor to the molecule choline. If you happen to drink less fluids one day, choline levels may increase and concentrate in the urine during the excretion process and resemble the scent of asparagine (the amino acid responsible for the scent after you eat asparagus).
†THESE STATEMENTS HAVE NOT BEEN EVALUATED BY THE FDA. THIS PRODUCT IS NOT INTENDED TO DIAGNOSE, TREAT, CURE, OR PREVENT ANY DISEASE.
